CSE-Miner Introduction

Immunotherapy with T-cells expressing chimeric antigen receptors (CARs) holds the promise to improve outcomes for children with solid and brain tumors. However, at present, there is a limited array of targetable antigens. We posit here that targets generated by alternative splicing events in cancer cells present an untapped class of CAR targets since many of these are tumor-specific and overexpressed in malignant cells.Thus, we developed Cancer-Specific Exon Miner (CSE-Miner), a pipeline for mining exon-based CAR-T targets

Click here for a brief tutorial of the app.

Drs. Stephen Gottschalk and Jinghui Zhang Lab. St Jude Children's Research Hospital. Maintained by Liqing Tian [email protected]